Continuous Non-invasive Blood Pressure Monitoring for Cardiovascular Screening

Background and Rationale
Cardiovascular diseases (CVDs) remain a major source of mortality and healthcare burden. Hypertension is a key modifiable risk factor, yet many people are undiagnosed or insufficiently controlled. Single “spot” measurements often miss masked hypertension and clinically relevant blood‑pressure variability. A low‑cost, comfortable and accurate non‑invasive method for continuous blood pressure (BP) monitoring is needed to support earlier detection, prevention and follow‑up.

Proposed Solution
We will develop a cuffless, non‑invasive continuous BP monitoring system using proprietary force sensors. Placed externally (e.g., wrist/over a superficial artery), the sensors capture the arterial pulse waveform beat‑to‑beat. Beyond systolic/diastolic values, continuous waveform recording enables morphology‑based screening: pulse contours and derived indices can indicate vascular function (e.g., stiffness/wave‑reflection changes) and help flag early cardiovascular alterations.

Objectives and Innovation
• Prototype: mature our proof‑of‑concept/breadboard into a robust wearable/portable device integrating sensor array, electronics, calibration and user interface.
• Analytics: develop signal processing and AI/ML models to extract clinically meaningful features, track BP trends, and derive risk indicators (e.g., stiffness indices, irregular pulse patterns) across patient groups.
• Clinical validation: run studies with hospital partners, benchmarking against reference methods in diverse cohorts and demonstrating the added value of continuous waveform data.
• Screening protocol: co‑design a fast, simple screening workflow (minutes per subject) with clear, actionable software outputs to guide follow‑up.

Consortium and Expertise
We seek a multidisciplinary consortium: (1) MedTech/industry partners for engineering, manufacturability and regulatory strategy; (2) hospitals/clinics for patient access and clinical evaluation; (3) universities/R&D teams for cardiovascular science, signal processing and data analytics. The initiating team contributes the in‑house force sensor technology and experience in diagnostic device development and data analysis.

Impact and Future Vision
The project will scale an innovative cardiovascular health technology from PoC to a clinically validated prototype. Comfortable continuous BP plus waveform‑based screening can enable earlier detection, improved risk stratification and more personalized management, while generating valuable datasets and paving a path to commercialization.