Jiksak Bioengineering

At Jiksak—where innovation meets neuron drug delivery and nerve repair. We're a biotech company dedicated to groundbreaking therapies for neurodegenerative disorders and nerve repair. Our technologies include:

·       Drug-Linked Carrier (DLC): An advanced drug delivery system utilizing motor neuron axons to bypass the Blood-Brain Barrier (BBB) and Blood-Spinal Cord Barrier (BSCB) for drug delivery into the CNS.

Publication: Yee, KKL et al. Molecular Therapy: Methods & Clinical Development (Vol. 33, Issue 2) ; ”Harnessing synaptic vesicle release and recycling with antibody shuttle for targeted delivery of therapeutics to neurons” https://www.sciencedirect.com/science/article/pii/S2329050125000713

·       Nerve Organoids: Human iPSC-derived nerve tissues that replicate the complexity of living nerves, ideal for predictive disease modeling and drug screening. 3D axon bundles derive from these nerve organoids are also used as innovative nerve repair scaffolds composed of acellular axonal tissues embedded within a biocompatible matrix, to guide effective nerve regeneration.

Publication: Nishijima, Takayuki, et al. Inflammation and Regeneration 44.1 (2024): 6."Novel artificial nerve transplantation of human iPSC-derived neurite bundles enhanced nerve regeneration after peripheral nerve injury." https://link.springer.com/article/10.1186/s41232-024-00319-4

·       Engineered Synaptogenic Beads: Protein-coated beads designed to mimic in vivo presynaptic formation, facilitating in vitro studies and accelerating discovery of therapeutic compounds for motor neuron repair.

Join us at the forefront of neuroscience innovation—partner with Jiksak to redefine what's possible in nerve repair and neurodegenerative treatment.