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PartnershipUpdated on 9 September 2025

Jiksak Neuron Drug Delivery System (NDDS) Platform for Neurodegenerative Disease Therapeutics

About

Neuron Drug Delivery System (NDDS) Platform:

NDDS utilizing motor neuron axons to bypass the Blood-Brain Barrier (BBB) and Blood-Spinal Cord Barrier (BSCB) for drug delivery into the CNS and drug accumulation in targeted neurons. It has the potential to deliver oligonucleotides and small molecules to selected neurons through intravenous administration. Two therapeutic pipelines are currently in development, and we are seeking additional strategic partners for co-development in other potential indications. DLC mode of mechanism have recently be published in Molecular Therapy journal.

Publication: Yee, KKL et al. Molecular Therapy: Methods & Clinical Development (Vol. 33, Issue 2) ; ”Harnessing synaptic vesicle release and recycling with antibody shuttle for targeted delivery of therapeutics to neurons” https://www.sciencedirect.com/science/article/pii/S2329050125000713

Organisation

Jiksak Bioengineering

Company (SME/startup) / 中小企業・スタートアップ

Kawasaki, Japan

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