Principal investigator
Spanish National Research Council (CSIC)
Madrid, Spain
We make use of protein engineering and nanobiotechnology for the development of non-covalent immobilization procedures of enzymes, especially oxidoreductases, to decolorate wastewater containing textile dyes making use of sustainable supports.
Spanish National Research Council (CSIC)
Spanish National Research Council (CSIC)
Public Administration
Madrid, Spain
The Protein Engineering against Antimicrobial Resistance Group at CIB-CSIC brings multidisciplinary expertise in structural biology, biophysics, protein engineering and advanced bioconjugation to combat multi-drug resistant (MDR) pathogens. Our primary focus is the development of next-generation antimicrobial strategies targeting critical respiratory pathogens such as Pseudomonas aeruginosa.
Key Research & Antimicrobial Development Lines:
Enzybiotics and Phage Endolysin Engineering:
Design, expression, and functional validation of wild-type and engineered phage endolysins targeting cell wall peptidoglycans.
Targeting Surface and Virulence Proteins:
Identification and inhibition of key bacterial surface proteins required for bacterial viability, colonization, and virulence, opening novel non-traditional antibiotic targets.
Multivalent and Nanobiotechnology Solutions:
Development of small molecules, bioactive peptides and functionalized nanoparticles displaying multivalent active compounds to exponentially increase bactericidal efficacy, with the bacterial cell membrane as target.
Synergistic Therapies
Evaluation of synergistic combinations between novel enzybiotics, antimicrobial peptides, nanoparticles and conventional antibiotics to prevent resistance development.
Additional information:
Additional questions
Region
Madrid Region (ES)
Expertise
Adding value to biopolymers through protein functionalization
We have an extensive background in protein engineering and stabilization that we have successfully used for efficient, tunable and non-covalent recombinant enzyme immobilization.
Expertise
Tackling Bacterial Disease With Multivalent, Surface-Targeted Nanostructures
Our group holds several research lines focused on the search for novel antimicrobials and on the study of protein immobilization strategies for biomedical applications.