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ExpertiseUpdated on 18 May 2026

Adding value to biopolymers through protein functionalization

Jesús Miguel Sanz

Investigador principal at Spanish National Research Council (CSIC)

Madrid, Spain

About

We have an extensive background in protein engineering and stabilization that we have successfully used for efficient, tunable and non-covalent recombinant enzyme immobilization and single-step purification procedures in biopolymers such as polyhydroxyalkanoates, as well as in other simple supports, ranging from nanoparticles to macroscopic matrices. We employ for this purpose affinity tags that were designed and developed in the laboratory. As an example, we have developed an oxidase-functionalized polyhydroxybutyrate minibioreactor able to decolorize wastewater effluents from the textile industry. We wish to apply this knowledge to generate high-added value supports functionalized with peptides or enzymes and that may be find their application in the biotechnological and biomedical field, for instance to generate enzymatic bioreactors based on sustainable supports, or protein-coated materials with antimicrobial properties.

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