Post Doctoral Fellowship in Proteases and Extracellular Matrix

The group “Proteases and Extracellular Matrix”, leaded by Dr. Juan Carlos Rodríguez-Manzaneque at GENYO. Centre for Genomics and Oncological Research, in Granada (Spain), is interested in hosting a Marie Curie Postdoctoral Fellowship. Dr Juan Carlos Rodríguez-Manzaneque is interested in studying the capacity of extracellular proteases to model the tumor microenvironment, particularly the immune infiltrates in close connection with the vascular niche. Such studies have special relevance for the understanding of mechanisms of drug resistance (such as antiangiogenic and immune-therapies) that certain tumors develop. The convergence of advanced platforms of genomic and proteomic analyses, together with the functional study of the phenotype of cells under various extracellular tumor scenarios, appeared as a consistent perspective to advance in the fight against tumor progression. Dr Rodríguez-Manzaneque has been devoted for many years to the study of extracellular matrix remodeling, mostly in the context of tumor plasticity and neo-vascularization. He developed his career in this field since his postdoctoral training at the laboratory of vascular biology world-leader Dr Iruela-Arispe (UCLA, USA). He has made unique contributions to the identification of substrates of ADAMTS proteases, its role in progression of a range of carcinoma types and its actions in tumor cell plasticity. Such studies have been reported in top journals such as PNAS, Cancer Research, Matrix Biology, Nature, Cancers, Cell Research, and others.

More information about the group: https://www.genyo.es/investigacion/grupos-investigacion/proteases-and-extracellular-matrix/

REQUIRED EDUCATION AND EXPERIENCE LEVEL

• Required education level: PhD or equivalent in Biological and/or Medical Sciences

• Main research field: Tumor Microenvironment, Tumor Immunology, Experimental Oncology

• Years of research experience: 5

• Language: English.

• Skills: Experience with tumor mouse models and immunology.

APPLICATION DETAILS

• How to apply: Send a letter of interest together with your CV and email addresses of 3 referees.

• Application e-mail : juancarlos.rodriguez@genyo.es

• Deadline for sending CVs: 09/07/2025

At the deadline for the submission of proposals (10 September, 2025), researchers:

• shall be in possession of a doctoral degree

• must have a maximum of eight years of experience in research, from the date of the award of their PhD degree, years of experience outside research and career breaks will not count towards the above maximum, nor will years of experience in research in third countries, for nationals or long-term residents of EU Member States or Horizon Europe Associated Countries who wish to reintegrate to Europe ( click for more information)

• must not have resided or carried out their main activities in the country of Spain for more than 12 months in the 3 years immediately prior to the above mentioned deadline.