Offering expertise of the group of Prof. Markus Scholz

Prof. Markus Scholz's team at the University of Leipzig specializes in bioinformatics solutions for single-cell sequencing, providing deep insights into cellular heterogeneity, gene regulation, and the molecular mechanisms underlying complex diseases. Their expertise spans the entire analytical pipeline, from data preprocessing to advanced interpretation.

Key areas of focus include:

·        Data Preprocessing and Quality Control: Ensuring reliable analysis by addressing noise, dropouts, and technical biases inherent in single-cell data.

·        Dimensionality Reduction and Clustering: Identifying cell populations, subtypes, and states using advanced methods like UMAP, t-SNE, and hierarchical clustering.

·        Gene Expression Analysis: Investigating gene regulatory networks and cell-specific expression patterns to uncover critical pathways and interactions.

·        Trajectory and Pseudotime Analysis: Mapping cellular differentiation and developmental pathways to understand dynamic biological processes.

·        Multi-Omics Integration: Combining single-cell transcriptomics, epigenomics, and proteomics for a comprehensive view of cellular function.

Applications of their bioinformatics expertise include:

·        Characterizing immune cell diversity in infectious and autoimmune diseases.

·        Mapping tumor microenvironments for cancer research and therapy development.

·        Investigating developmental biology and stem cell differentiation.

Through state-of-the-art computational tools and algorithms, the team delivers high-resolution insights that empower researchers to address fundamental biological questions and drive innovation in precision medicine.