Ageing and Chronic Diseases

UAH researcher's work on identifying novel biomarkers and therapeutic targets, alongside preclinical assessment of natural and biotechnological compounds, aiming to advance personalised medicine and improve quality of life in chronic conditions.

Research groups:

• Therapeutic Innovations: Investigating immunomodulatory polyphenols, comparing efficacy of biotechnological drugs and exploring natural products with anti‑aggregant and antioxidant activities.

• Translational Individualised Medicine in Inflammation and Cancer: Analysing intestinal dysbiosis and bacterial translocation; identifying biomarkers such as Dido and p21. Developing immunotherapy and tissue‑regeneration strategies for inflammatory diseases and tumours.

• Physiopathology of the cardiovascular, renal and nervous systems: Studying injury and repair mechanisms in cardiac, renal and neural tissues, including the role of ILK, bisphenol‑A effects and atheroma plaques, in cellular and animal models.

• Cell damage associated with senescence: Investigating endothelial microvesicles and microRNAs as biomarkers of cellular ageing and therapeutic targets in cardiovascular diseases linked to chronic kidney disease.

Key services offered:

• Cell culture, isolation and characterisation of extracellular vesicles

• Functional cellular assays, senescence measurements and quantitative PCR

• Western blot analysis and molecular‑signalling studies

• Evaluation of natural compounds: antioxidant and anti‑ageing cosmeceutical formulations

• R&D advisory, experimental design and technology‑transfer support

Current projects:

• Development of a depigmenting and antioxidant cosmeceutical formulation based on caffeic‑acid‑functionalised nanoparticles (Cell damage associated with senescence)

• Studies on intestinal dysbiosis in relation to chronic venous insufficiency and spinal injury (Translational Individualised Medicine)

• Inhibition of hydrogen‑sulphide synthesis to activate macrophages for leishmaniasis control (Physiopathology of the cardiovascular, renal and nervous systems)

• Evaluation of bacterial lactase’s therapeutic potential on tumour cells (Therapeutic Innovations)