RCSI: Leading Expertise in Pharmacoepidemiology, Polypharmacy, Deprescribing for Safer Medication Use

The Royal College of Surgeons in Ireland (RCSI) University of Medicine and Health Sciences is seeking to contribute as partners for HORIZON-HLTH-2027-01-CARE-02: Personalised approaches to reduce risks from Adverse Drug Reactions due to administration of multiple medications. This topic aims to reduce adverse drug reactions associated with polypharmacy through personalised medicine approaches, real-world data, and improved clinical decision support.

RCSI offers extensive expertise in:

• Pharmacoepidemiology and real-world evidence studies

• Polypharmacy, multimorbidity, and medication optimisation

• Deprescribing intervention development and evaluation

• Adverse drug reaction surveillance and medication safety research

• Analysis of large-scale healthcare and electronic health record datasets

• Clinical and population-level evaluation of prescribing quality

• Implementation science and translation of evidence into healthcare practice

• Health services research and health economic evaluation

• Development and assessment of decision-support tools for medicines optimisation

Potential contributions to a CARE-02 consortium include:

• Leadership of work packages on pharmacoepidemiology, medication safety, and real-world evidence generation

• Identification of risk factors for adverse drug reactions in patients exposed to multiple medications

• Design and evaluation of deprescribing and medication optimisation strategies

• Development of evidence-based approaches to reduce inappropriate polypharmacy

• Assessment of intervention effectiveness, implementation, and scalability across healthcare systems

• Support for clinical, regulatory, and health-system integration of project outputs

We are particularly interested in collaborating with clinical, digital health, personalised medicine, pharmacogenomics, AI, health data, patient organisation, and healthcare implementation partners to develop innovative approaches that improve medication safety and outcomes for patients experiencing polypharmacy.