Advancing Horizon Europe projects through microbiota and metabolomics for translational and clinical research

Prof. Silvia Angeletti is a Full Professor of Clinical Microbiology at Università Campus Bio-Medico di Roma, with consolidated expertise in microbiota research, metabolomics and host–microbe interactions in both clinical and translational settings.

Her research focuses on understanding how microbial communities and their metabolic outputs influence human health and disease, integrating microbiological, metabolomic and clinical data to identify biomarkers, therapeutic targets and predictive signatures relevant to patient stratification and personalized medicine.

Key areas of expertise include:

• Human microbiota profiling in health and disease

• Metabolomics approaches for the study of microbe-derived and host metabolites

• Host–microbiota interactions in inflammatory, infectious and systemic diseases

• Integration of multi-omics data (microbiota, metabolomics, clinical parameters)

• Identification and validation of biomarkers for diagnosis, prognosis and treatment response

Prof. Angeletti has strong experience in multidisciplinary and international research projects, working at the interface between basic science, clinical research and systems biology. Her contribution to Horizon Europe consortia is particularly valuable for projects requiring a translational and clinically relevant interpretation of microbiota and metabolomics data.

She is interested in participating in Horizon Europe collaborative projects as a partner contributing:

• Expertise in study design and interpretation of microbiota and metabolomics data

• Access to well-characterized clinical cohorts and biological samples

• Support in multi-omics integration and biomarker discovery

• Clinical validation and translational exploitation of project results

She is particularly open to collaborations addressing:

• Microbiota-driven mechanisms of disease

• Microbiome-based diagnostics and therapeutic strategies

• Diet, metabolism and host–microbe crosstalk

• Personalized and precision medicine approaches

• One Health and systems biology frameworks

The Campus Bio-Medico of Rome provides a highly integrated clinical and translational research environment, enabling the effective exploitation of microbiota and metabolomics research within Horizon Europe projects and enhancing their scientific and societal impact.