NGS-based molecular diagnostics for lymphoproliferative diseases in Horizon Europe projects

Prof. Silvia Angeletti is a Full Professor of Clinical Microbiology at Università Campus Bio-Medico di Roma, with consolidated expertise in molecular diagnostics and next-generation sequencing (NGS) applied to clinically complex diseases, including lymphoproliferative disorders.

Her research activity focuses on the implementation and clinical validation of NGS-based molecular approaches to improve diagnostic accuracy, disease classification and patient stratification in lymphoproliferative diseases. She works at the interface between advanced laboratory technologies and clinical decision-making, supporting precision and personalized medicine.

Key areas of expertise include:

• NGS-based assays for molecular characterization of lymphoproliferative diseases

• Clonality assessment and immune repertoire analysis

• Detection of somatic mutations, rearrangements and molecular biomarkers

• Minimal residual disease (MRD) monitoring using high-sensitivity molecular tools

• Integration of molecular, clinical and laboratory data for diagnostic and prognostic purposes

• Validation and standardization of NGS workflows in a clinical diagnostic setting

Prof. Angeletti has strong experience in multidisciplinary and international research collaborations, working closely with clinicians, molecular biologists and bioinformaticians to translate NGS data into clinically actionable information.

She is interested in participating in Horizon Europe collaborative projects as a partner contributing:

• Expertise in molecular diagnostics and clinical validation of NGS technologies

• Access to well-characterized clinical samples and patient cohorts

• Support in study design, assay optimization and data interpretation

• Contribution to translational pathways and regulatory-ready diagnostics

She is particularly open to collaborations addressing:

• Innovative NGS-based diagnostic and prognostic tools

• Precision medicine approaches in hematological malignancies

• Early diagnosis and disease stratification

• Integration of NGS and digital tools, including AI-driven analysis

• Clinical validation and implementation of advanced molecular diagnostics

The Campus Bio-Medico of Rome offers a highly integrated clinical and translational research environment, enabling the effective development, validation and clinical adoption of NGS-based diagnostic approaches within Horizon Europe consortia.