A Validated, Regulatory-Ready Organoid Platform for Neurotoxicity

The Innovation

We are developing a Human Organoid-on-Chip platform to screen for microplastic-induced neurodegeneration. Crucially, we are validating this NAM against advanced MRI imaging and pilot animal data to ensure high predictive reliability.

Partners Secured (The "Heavy Lifting" is Done)

• ✅ Biology: Human Brain Organoid experts.

• ✅ Chemistry: MNP synthesis & Spectroscopic detection.

• ✅ Validation: Established pilot animal protocols (Inhalation/Oral) & MRI imaging.

• ✅ Pathology: RT-QuIC assays for Tau/α-synuclein aggregation.

Partners We Are Seeking

1. Microfluidic / Chip Engineer (Priority)

• Role: Design the "Hardware Interface" for the organoids (simulating blood flow/BBB).

• Keywords: Bio-MEMS, Organ-on-Chip, Microfluidics.

2. Regulatory Science & Safety Assessment

• Role: Ensure the NAM platform meets the criteria for regulatory acceptance.

• Tasks: Define Adverse Outcome Pathways (AOPs), assist with OECD validation guidelines, and ensure alignment with REACH/chemical safety frameworks.

• Keywords: Regulatory Toxicology, NGRA (Next Generation Risk Assessment), AOPs, OECD.

3. Microbiome Specialist

• Role: Formulate a probiotic Medical Countermeasure (MCM) to be screened on the platform.

Why Join MP-NEURO-NAM?

• High TRL Potential: We aren't starting from scratch; we have the plastics, the tissues, and the validation data ready.

• Policy Impact: With the inclusion of a regulatory work package, we aim to produce a method that creates real policy change in chemical safety testing.