Integrated NAM platforms combining engineered devices, sensing, omics and simulation

Our centre contributes a comprehensive and integrated capability to the development, validation and uptake of advanced New Approach Methodologies (NAMs) through the convergence of engineered platforms, embedded sensing technologies, biological models and advanced simulation.

The Plastics Composites and Processing (PCP) unit can design and fabricate medical-grade devices based on silicone or polypropylene, enabling the embedding of electronics and sensors within in-vitro–compatible implantable or semi-implantable systems.

Through the Functional Printed and Embedded Devices (FPED) unit, we integrate embedded and printed sensors into Organ-on-Chip platforms, enabling real-time monitoring of media composition and dynamic biological responses under controlled conditions.

The Advanced Manufacturing Systems (AMS) unit contributes optical sensing technologies based on light–matter interaction, enabling non-invasive monitoring within NAM platforms and supporting high-precision data acquisition.

The Nutrition and Health unit provides expertise in in-vitro and human ex-vivo assays, including organoids, Organ-on-Chip systems, human tissue models and induced pluripotent stem cell (iPSC)-based applications, ensuring biological relevance and translational value.

The Omics Science unit performs multi-omics characterisation of NAM systems, generating molecular-level evidence to validate predictive capacity and mechanistic fidelity.

Finally, the Product Innovation and Multiphysics Simulation (PIMS) unit develops advanced multi-physics simulations integrating data from soft tissues, hard tissues and fluid dynamics, supporting interpretation of experimental results and enabling clinically relevant decision support.

Together, these capabilities strengthen the credibility, robustness and regulatory relevance of next-generation NAM platforms aligned with EU health research priorities.