Digital Mental Health NAMs Based on Multimodal Digital Twins

Mential positions Digital Twins and digital phenotyping as a New Approach Methodology (NAM) for mental health research and regulatory assessment. By replacing static questionnaires with continuous, real-world behavioural and emotional markers, the platform enables more human-relevant and scalable research methods.

Example activities include:

• Defining digital mental health NAMs based on structured behavioural markers.

• Comparing Digital Twin-based endpoints with traditional observational methods.

• Supporting pharmaceutical and public research projects with digital surrogate endpoints.

• Integrating digital NAMs into regulatory testing workflows.

Mential’s differentiation lies in real-time, multimodal, clinically structured data. Most NAMs focus on biological or in-vitro models; Mential uniquely addresses the behavioural and psychological dimension using interoperable, regulator-ready digital infrastructure.