Development of human vascularized organ-on-chip systems as New Approach Methodologies (NAMs) for disease modeling and drug testing

DR. SHIRA LANDAU-LEVI

I offer expertise in the development of human vascularized organ-on-chip systems as New Approach Methodologies (NAMs) for disease modeling and drug testing. My work focuses on engineering perfusable microvascular networks integrated with functional human tissues, including cardiac and multi-organ platforms, to capture physiologically relevant tissue–vascular–immune interactions. I bring experience in microfluidic device design, advanced 3D culture strategies, and quantitative functional readouts of vascular integrity, inflammation, and tissue stress responses. These platforms are designed to improve translational predictability compared to conventional 2D cultures and animal models, and are well suited for mechanistic studies, safety assessment, and evaluation of therapeutic interventions, supporting the broader adoption of NAMs in biomedical research.