Mechanisms of sexual dimorphisms

My lab is expert is mammalian sex determination, using the mouse as a model system. We have developed a system where upon minor genetic perturbations, we have four models of mice that enable to distinguish the effect of sex chromosomes (XY/XX) from gonadal sex hormones (Testosterone, Estrogen). We have normal XY males and normal XX females but also XY females (sex reverse) and XX males (sex reverse). By breeding these four types of mice into a mutation that causes heart problem we can explore if the sex difference stem from a sex chromosome difference or hormonal effect. Our new model is superior to the original four core genotyping (FCG) model that is heavily used to study sex differences and sexual dimorphism.

I am looking to contribute via experimental setting in mice that could shed light into how sex chromosomes or sex hormones mediate the difference in cardiovascular diseases between males and females.