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Project cooperationUpdated on 27 May 2026

Sex-specific molecular mechanisms with endothelial cells from dizygotic twin pairs

Senior Scientist at Deutsches Herzzentrum der Charité; Klinik für Kardiologie, Angiologie und Intensivmedizin, CCM

Berlin, Germany

About

We are studying sex differences at the cellular level with human endothelial cells from umbilical cords (HUVEC). Thereby, we are working with endothelial cells from dizygotic female/male twin pairs. They have the advantage that they are during pregnancy subjected to the same maternal life style and environmental factors. In addition, they share 50% of their genomes, thus further reducing inter-individual variability. These features make them especially suitable to elucidate hormone-independent sex-specific molecular mechanisms and functional pathways at the cellular level.

Topic

  • DESTINATION 3: HORIZON-HLTH-2026-01-DISEASE-11: Understanding of sex and/or gender-specific mechanisms of cardiovascular diseases: determinants, risk factors and pathways
  • DESTINATION 3: HORIZON-HLTH-2026-01-DISEASE-15: Scaling up innovation in cardiovascular health

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