Methods to assess sex, hormone, genetic, and physiologic population differences

We are establishing a range of laboratory methods to assess the effect of biological sex on drug responses.

Specifically, we are establishing high-throughput screening assays for a range of in vitro model systems from both sexes, incubated in the presence or absence of sex-hormones (estrogen, progesterone, testosterone). We perform high-content imaging (e.g., morphological profiling), requiring no prior knowledge on drug effects, and benchmark with methods assessing both gross toxicity as well as organ-specific functional readouts.

What we offer:

• High-throughput screening assays to map and assess sex-specific responses.

• Methodologies to assess hormonal influences, genetic predispositions, and/or physiological differences between different populations.

• High-throughput/high content laboratory methods based on cell lines, organoids, or primary cells to train and/or validate AI-predictions.

We are looking for:

• Partners with relevant complementary expertise or methodologies to join consortia.

• Partners with relevant use cases where sex is relevant as a biological variable.

We are open to joining existing consortia or coordinating new proposals.