TOXIMIND

Primary Objectives:

To quantitatively and spatially map the accumulation of selected heavy metals (e.g., Hg, Pb, Cd, Al, As) and micro/nanoplastics in specific brain regions affected in neurodegenerative diseases.

Secondary Objectives:

• To compare pollutant accumulation patterns between disease groups and controls

• To identify co-localization of pollutants with neuropathological hallmarks (Aβ, tau, α-synuclein, TDP-43)

• To assess regional vulnerability to environmental pollutants in the human brain