Associate professor in functional genomics of connective tissue disorders
University of Antwerp- Faculty of Medicine and Health Sciences
Antwerp, Belgium
Prof. Verstraeten is an ERC starting grant recipient developing and using advanced mouse and iPSC-derived models to uncover the mechanisms of arterial/aortic aneurysms with the aim of identifying novel therapeutic targets and developing new therapies.
Aline Verstraeten is an associate professor at the University of Antwerp and head of the Connective Experimental Omics (CONNEX) research team at the Center for Medical Genetics, where she leads preclinical research on connective tissue disorders. She obtained her PhD in 2015 on next‑generation sequencing-based gene identification for Parkinson disease under the supervision of Prof. Christine Van Broeckhoven, and subsequently completed a Research Foundation Flanders (FWO)-funded postdoctoral fellowship with Prof. Bart Loeys on the genetics of heritable thoracic aortic diseases. During this period, she developed a growing interest in preclinical research, which she further cultivated through international research stays with Prof. Hal Dietz (Johns Hopkins University, Baltimore, USA) and Prof. Petra Knaus (Freie Universität Berlin, Germany).
She has contributed to the identification of novel disease genes, including IPO8—now a central focus of her lab—and, together with her team, is dedicated to advancing improved model systems such as aorta-on-chip platforms, alongside using sophisticated mouse and iPSC-derived models to unravel disease mechanisms and identify therapeutic targets. In 2024, she was awarded an ERC Starting Grant, recognizing the promise of her lab’s work to drive discoveries with real translational impact. Her focus on rare diseases namely reflects a deliberate and deeply rooted commitment to patients, guided by the belief that everyone, no matter how rare their condition, deserves a future shaped by possibility. Alongside her academic career, she is a mother of three amazing young sons and enjoys spending time in nature with her family.
The ERC-funded CONNEX lab is looking for candidates eager to assess how IPO8 loss alters aortic vascular smooth muscle cell and fibroblast states, impairs communication, and drives inflammation and macrophage recruitment.
The ERC-funded CONNEX lab is looking for candidates eager to push the preclinical aortic disease research field forward by establishing and characterizing patient and control aorta-on-a-chip models.
Join forces with, and complement the research of, the ERC-funded CONNEX lab in Antwerp to advance preclinical TAA research, with cutting-edge expertise in transcriptomics, mouse modelling and aorta-on-a-chip creation.