Guillaume MILLET

I'm an Exercise physiologist specialised notably in the study of the mechanisms of fatigue, both in extreme sports (ultra-endurance, high altitude) and in clinical settings (neuromuscular diseases, cancer, ageing, resuscitation). Senior member of the Intitut Universitaire de France (IUF), I was Professor at the University of Calgary (Canada) before returning to UJM in France to serve as Director of the Inter-University Laboratory of Motor Biology (LIBM), found the ActiFS Chair on Physical Activity, Fatigue and Health and more recently the PATHS graduate school on Physical Activity, Training and Health in Sport science.

Author of over 350 scientific articles and six reference books on physiology, training and endurance sports, I'm also a former ultra-trail competitor (three times in the top six of the UTMB), connecting my personal practice to my research at physiology, neurophysiology and biomechanics. My main contributions include:

• Activation reduction during prolonged exercise, particularly running, with a non-linear increase in fatigue as a function of distance, independent of sleep deprivation.

• The demonstration of a direct effect of hypoxia on central control, explaining the decline in performance at altitude, beyond the simple reduction in muscle oxygenation.

• The development of an explanatory model of fatigue (‘The flush model’) and the development of innovative methodologies for its assessment

• The exploration of links between chronic fatigue and exercise tolerance, opening up avenues for the management of various conditions.