Marco Mangiagalli

I am an Assistant Professor at the Department of Biotechnology and Biosciences, University of Milano-Bicocca, actively looking to host and supervise motivated MSCA Postdoctoral Fellows.

I recently awarded the highly competitive FIS2 Starting Grant from the Italian Ministry of University and Research as Principal Investigator. My lab investigates the molecular mechanisms of enzyme temperature adaptation, combining ancestral sequence reconstruction with deep-learning enzyme design to engineer synthetic enzymes with tunable thermal properties.

We welcome project proposals that align with our core expertise, which includes:

• Enzyme Adaptation: Investigating cold-adaptation mechanisms in cold-active enzymes through combined structural, functional, and computational analyses.

• Industrial Biocatalysis: Improving the stability and solvent tolerance of industrially relevant enzymes, focusing on their application in non-conventional media.

• Sustainable Bioprocessing: Developing strategies for recombinant protein and enzyme production in Escherichia coli using agro-food waste streams as feedstock.

As a fellow in my group, you will benefit from a dynamic, interdisciplinary environment bridging computational design, structural biology, and applied biotechnology.