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Clyde Francks

Professor of Brain Imaging Genomics

Imaging Genomics Research Group

Nijmegen, Netherlands

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Prof. dr. Clyde Francks leads the Imaging Genomics research group at the Max Planck Institute, Nijmegen, The Netherlands

My organisation

The Imaging Genomics research group, led by Prof. dr Clyde Francks, studies the genetics of language, brain disorders and laterality of the brain. For most people, the left and right sides of the human brain specialise in performing different functions and processing different types of information - in fact, much of our cognition is relatively lateralized to one side or the other. Language is an excellent example of this lateralized function; in most people, several component processes are performed in the left side of the brain. The Imaging Genomics group is especially interested in genes that are involved in establishing how the two hemispheres develop and function differently, for example by affecting how the nervous system develops in the embryo. Although it has been established that left-right asymmetry plays an important role in the way in which the human brain is organised, very little is known about the underlying molecular mechanisms. Our team of researchers is working hard to uncover new knowledge in this area.
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About me

Prof. dr. Clyde Francks leads the Imaging Genomics research group at the Max Planck Institute, Nijmegen, The Netherlands. He is also Professor of Brain Imaging Genomics at the Medical Neuroscience Department and Donders Institute for Brain, Cognition & Behaviour at Radboud University Medical Center. His group studies the genetics of language, brain disorders and asymmetry of the brain on its left to right axis. Some examples of research papers from the group:

Exome-wide analysis implicates rare protein-altering variants in human handedness. Nature Communications 2024.

Handedness and its genetic influences are associated with structural asymmetries of the cerebral cortex in 31,864 individuals. Proceedings of the National Acadamy of Sciences 2021.

The genetic architecture of structural left–right asymmetry of the human brain. Nature Human Behaviour 2021.

Altered structural brain asymmetry in autism spectrum disorder in a study of 54 datasets. Nature Communications 2019.

Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium. Proceedings of the National Acadamy of Sciences 2018.

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Skills

  • Research Group Leader
  • Brain Imaging Genomics
  • Large-scale studies
  • Human neurogenetics
  • human genetics
  • Consortium studies
  • neuroscience
  • Neurobiology

Interests

  • Brain asymmetry
  • Hemispheric specialization
  • Autism
  • schizophrenia
  • Dyslexia
  • Polygenic scores
  • Rare genetic variants
  • GWAS
  • Genetic epidemiology
  • Behaviour genetics
  • neuropsychiatric disorders
  • Left-handedness
  • Genome sequencing
  • Exome sequencing
  • spatial transcriptomics

Marketplace (1)

  • Project cooperation

    Hosting Postdoctoral Fellows in Brain Imaging Genomics

    Happy to support applications from talented prospective postdoctoral fellows to join the Imaging Genomics Research Group

    • MSCA-DOCTORAL NETWORKS
    • MSCA-POSTDOCTORAL FELLOWSHIPS
    • POSTDOCTORAL FELLOWSHIP: Looking for Fellow
    • DOCTORAL NETWORK: Looking for Partner/s (Beneficiaries or Associated Partners)
    Author

    Clyde Francks

    Professor of Brain Imaging Genomics at Imaging Genomics Research Group

    Nijmegen, Netherlands