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Dorthe Helena Larsen

Group Leader

Danish Cancer Institute

Copenhagen, Denmark

3 profile visits

I investigate instability of the ribosomal DNA, a repetitive genomic region, to understand how it affects fundamental processes and human diseases.

My organisation

Danish Cancer Institute

Danish Cancer Institute

Research Centre

Copenhagen, Denmark

An research institute.
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About me

I am a Group Leader at the Danish Cancer Institute in Copenhagen, Denmark. I have a strong background in molecular biology that I use to provide new insights into human diseases.

My research concentrates around genome instability and how it causes human diseases, in particular cancer. We have specialized in maintenance of the ribosomal DNA that is found in the nucleolus and encodes the ribosomal RNA needed for ribosome biogenesis. Our work has elucidated a specialized nucleolar DNA damage response (n-DDR) and we continue to investigate its composition. Furthermore we analyse how cellular homeostasis is perturbed as a consequence of rDNA instability and the link to human diseases.

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Skills

  • Nucleolus
  • ribosomal DNA integrity
  • genome instability
  • n-DDR
  • DNA damage response
  • project management
  • Supervision
  • team building
  • Molecular analysis in tissues

Interests

  • Nucleolus
  • ribosomal DNA
  • genome instability
  • nuclear organization
  • organelle biology
  • cancer
  • aging
  • bone marrow failure
  • Dyskeratosis Congenita
  • liquid-liquid phase separation
  • chromatin structure and organization
  • micronuclei

Marketplace (1)

  • Expertise

    Ribosomal DNA stability

    Our research group investigates the mechanisms that protect the integrity of the ribosomal DNA and how its destabilization causes diseases.

    • LIF - Life Sciences
    • DOCTORAL NETWORKS: Hosting Doctoral Candidates / Secondments / Trainings
    • POSTDOCTORAL FELLOWSHIPS: Hosting Postdoctoral Candidates / Secondments / Placements
    Author

    Dorthe Helena Larsen

    Group Leader at Danish Cancer Institute

    Copenhagen, Denmark