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Yolanda Perez

Senior Researcher/NMR core lead

BioNMR-IQAC

Barcelona, Spain

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I am a senior researcher in the Biotransformation Group and the NMR Core Lead at the Institute of Advanced Chemistry of Catalonia (IQAC-CSIC).

My organisation

BioNMR-IQAC

BioNMR-IQAC

Researcher / Fellows

Barcelona, Spain

IQAC-CSIC, located in Barcelona, is part of the Spanish National Research Council (CSIC). With a long-standing tradition dating back to 1967 and independent status since 2007, IQAC-CSIC is committed to excellence-driven research in Chemical Sciences, aiming at improving quality of life, focusing on human health, sustainable processes and chemical products, and the development of new materials. This goal is pursued through a multidisciplinary approach, bringing together experts in Chemistry, Pharmacy, Biology, Biochemistry, Bioinformatics, and Chemical Engineering, providing the institute with a broad spectrum of research lines and fostering interdisciplinary collaboration. A well-rounded approach to chemical and biological research supports excellence in synthetic chemistry and (bio)molecular engineering with advanced laboratories, cell culture units, an animal facility, an insectary, and computational resources. IQAC-CSIC also stands out in knowledge transfer, with a strong patentoutput and industry ties, which facilitate the transfer of innovations between the laboratory and society.
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About me

Since 2010, I have been the scientific and technical manager of the NMR facility at the IQAC-CSIC. In 2024, I joined the IQAC Biotransformation group as a senior researcher and co-IP of research projects, contributing my expertise in NMR spectroscopy and molecular biology to the team's initiatives. My scientific interests focus on the use of NMR in combination with other biophysical techniques for the structural characterization of biomolecules and the study of the molecular recognition processes and non-covalent interactions in solution in which they participate, from the formation of intermolecular complexes to the intramolecular interactions, in order to understand the structure, function and interactions of biologically important molecules at the atomic, molecular and supramolecular scales. Thus, I have built a multidisciplinary research career using my expertise in diverse fields such as chemical biology, biochemistry and molecular biology, protein NMR and characterization of protein-ligand interactions. My major scientific contributions include the structural characterization of the Src protein kinase using NMR, SAXS and computational approaches, and my involvement in two drug discovery projects targeting the Stat6 and Sema3A proteins. In recent years, I have been working on sensors for the diagnosis and monitoring of certain human diseases and the use of (supra)molecular systems for therapeutic purposes. Since October 2023, I have served as the secretary and board member of the NMR Specialized Group of the Spanish royal Society of Chemistry (GERMN-RSEQ).

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Skills

  • NMR
  • LigandScreening
  • MolecularBiology
  • MolecularRecognition
  • DisorderedProteins
  • enzymes
  • Supramolecular

Interests

  • Biocatalysis
  • IntegrativeStructuralBiology
  • IDPs
  • ArtificialMetalloenzymes
  • NMR
  • SAXS

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