Personalized Bone Regeneration via Immunomodulatory GBR/BSM Platforms

We propose a novel approach to personalized bone regeneration by developing immunomodulatory Guided Bone Regeneration (GBR) membranes and Bone Substitute Materials (BSMs) tailored to each patient’s immune and healing profile. Unlike conventional “one-size-fits-all” solutions, our platform enables material-level personalization, not only in shape or size, but in biological function—guided by patient-specific biomarkers (e.g., cytokine levels, immune phenotypes). Advanced therapeutic medicinal products (ATMPs) proposed promising alternative therapeutic modalities by application of cell-based and tissue engineering approaches. Cell-based therapies are likely to be clinically supported by the new ATMPs, innovative fabrication processes, and enhanced surgical approaches. The development and standardization of methodologies is still a major challenge.