Nanoparticles with antimicrobial properties

There are several antimicrobial materials on the market to prevent or treat microbial infections. Despite the large number of strategies developed in recent decades, there is still a need for effective and affordable treatments for infected wounds that can address more than one aspect of antimicrobial treatment. Nanoparticles which can have intrinsic antimicrobial activity, are good candidates for this purpose. In addition, these nanoparticles can enhance their antimicrobial activity by loading hydrophilic or hydrophobic molecules with antimicrobial properties.

Description

In this cutting-edge, we offer the possibility of preparing complexes composed of nanoparticles with or without molecules. The nanoparticles with antimicrobial properties can be prepared using the DELOS-SUSP method or other methods which can allow the preparation of nanoparticles while hydrophobic and hydrophilic drugs could also be encapsulated. A complete physicochemical characterization is then performed using different techniques such as DLS, ELS, MADLS, MLS, NTA, etc. This is followed by an evaluation of the antimicrobial performance of the complexes. In this step, the adhesion of microorganisms to surfaces under different conditions is studied. The formation of biofilms and microbial viability is also investigated.

Examples of CIBER BBN collaborative intramural  projects implementing this Cutting-Edge Biomedical Solution:

Antimicrobial nanostructured biomaterials for complex wound healing (NABIHEAL), 101092269, European Union’s Horizon Europe research and innovation program, 01/01/2023-31/12/2026.

More info: https://www.nanbiosis.es/antimicrobial-nanoparticles/