Peptides for biomedical applications in animal models

The delivery of therapeutically relevant amounts of drugs to specific tissues or organs is one of the major challenges in nanomedicine. Peptides have emerged as promising targeting molecules for nanomedicines due to their cost-effectiveness and ease of modification, and their conjugation to nanocarriers can specifically deliver therapeutic agents to target tissues. Selection of the appropriate targeting moiety is a critical step that should be validated in vitro and, more importantly, by in vivo biodistribution in a mouse model to assess its ability to cross some biological barriers, such as the blood-brain barrier (BBB), and its capacity to be accumulated in specific tissues or organs. The use of fluorescently labeled targeting units (peptides or small molecules) can facilitate the study of the behavior of the selected targeting unit and facilitate its selection prior to its incorporation on the nanomedicine.

Description

In this cutting-edge, we offer the custom synthesis of fluorescently labeled peptides and the fluorescent labeling tailored to your specific nanoparticles to study their specific accumulation in the target tissues or organs. This labeling allows us to study the biodistribution of these peptides in vitro and in vivo using fluorescence or bioluminescence imaging. Different mouse models are available to determine the biodistribution of the peptides and nanomedicines, such as   healthy mice or oncology mouse models. In addition, we can determine their cellular localization through histological processing.

More info: https://www.nanbiosis.es/peptides-in-animal-models/