Biosensing based on BioFET

The importance of specific and label-free detection of proteins via antigen-antibody interactions for the development of point-of-care testing devices has greatly influenced the search for a more accessible, sensitive, low cost and robust sensors. The vision of silicon field-effect transistor (FET)-based sensors has been an attractive venue for addressing the challenge as it potentially offers a natural path to incorporate sensors with the existing mature Complementary Metal Oxide Semiconductor (CMOS) industry; this provides a stable and reliable technology, low cost for potential disposable devices, the potential for extreme miniaturization, low electronic noise levels, etc. In our lab we explore novel designs of field-effect devices for biosensing. The research involves device 3D finite-difference numerical calculations, analytical modeling, device development and fabrication, device electrical measurements and sensing experiments.