Crysforma: Solid State Development

Crysforma provides complete scientific support for the discovery, analysis and scale-up of polymorphs, hydrates, amorphous phases, salts and co-crystals of active pharmaceutical ingredients or intermediates.

The main working areas are:

• The modification of the solid state properties of active compounds to obtain the most suitable for the desired application (polymorphism, salts and co-crystal screenings).

• The optimisation of crystallisation processes to improve the development stages and to obtain the solids with the desired properties (purity, particle size, polymorph, morphology,…).

• The characterisation of the solid state of drug substance and drug product (PXRD, SCXRD, microED, DSC, TGA, DVS, PSD, IR, Raman, NMR, synchrotron…).

• Supporting the IP protection of new generated solid forms.

Crysforma has developed its own crystallisation screening methodology based on the combination of several crystallisation techniques and the individual monitoring of the experiments by highly skilled scientists to maximise the information extracted from each crystallisation. Our projects are always carried out in close collaboration with the client, adapted to the customer’s needs and under strict confidentiality conditions.