CLIPS-tricycle mRNA library-screening platform

Biosynth recently developed a novel high-throughput mRNA-screening platform for the discovery of highly specific tricyclic peptide binders to a target protein of choice. The peptides exist as a single isomer, precluding the need for identifying and isolation of the active isomer from a complex mixture of different isomers. The peptides display excellent stability against proteolytic degradation thanks to the presence of an organic scaffold that supports both the active conformation of this unique macrocyclic structure.