Tailored bioreactors for advanced 2D and 3D cell culture and tissue construct development a testing

We offer for cooperation a suite of fully customizable bioreactors designed to support collaborative R&I. Our technology replicates a wide spectrum of physiologically relevant mechanical and biochemical conditions, enabling precise control of shear stress, pulsatile pressure, and mechanical strain, while significantly improving nutrient diffusion and mass transport. By recreating in vivo–like microenvironmental cues, these bioreactors enhance cell viability and regulate key biological processes—including proliferation, differentiation, gene expression, and extracellular matrix remodeling. This platform provides a robust foundation for joint research on advanced 2D and 3D tissue models, contributing to innovation in regenerative medicine, disease modeling, drug testing, and next‑generation biomedical technologies.

Key Technical Features

1. Modular cultivation chambers for 2D and 3D constructs

• Interchangeable chamber designs support both planar (2D) and volumetric (3D) samples.

• Optimized for nutrient exchange and application of mechanical stimuli tailored to construct geometry.

• Laminar-flow operation with customizable microchannel architectures based on substrate type.

• Compatible with planar, tubular, porous, and irregularly shaped biomaterials.

• Fully modular design enabling scalability and user-defined modifications.

2. Controlled pulsatile and steady-flow perfusion

• Supports micro- to macrofluidic flow ranges with high temporal resolution.

• Independent control of flow rate, waveform generation, and pulsatility profiles.

• Integrated systems for hydrostatic pressure stimulation.

• Enables precise simulation of physiological environments such as vascular, musculoskeletal, or renal microenvironments.

3. Support for 3D tissue remodeling and maturation

• Active perfusion promotes efficient media exchange, including automated fresh‑media cycling for long-term culture.

• Enables remodeling of 3D‑printed or biofabricated tissues, including cell organization, multilayer overgrowth, and tight‑junction formation.

• Demonstrated compatibility with differentiation protocols (e.g., smooth muscle cells, osteogenic lineages) and maturation of endothelial layers.

4. Laboratory‑ready, sterile, and robust design

• Designed for seamless integration into standard CO₂ incubators without modifying culture infrastructure.

• All components are fully sterilizable (autoclavable chambers and tubing).

• Employs standard Luer‑lock fittings and disposable tubing systems for sterile handling.

• Remote monitoring and 24/7 operational capability for long‑term experiments.

• All cell‑contact materials are biocompatible and traceable, including machined polycarbonate and 3D‑printed FormLabs BioMed Clear resin.