Human multi-organ Organ-on-Chip platform integrating bioprinting, iPSCs, biosensors and AI to deliver ISO 13485-ready NAMs.

Design and development of Organ-on-Chip models, including:

• Gut-on-chip (permeability and nutrient absorption)

• Joint-on-chip (osteoarticular disease models: cartilage, tendon, synovial membrane)

• Tumour-on-chip (personalised cancer models)

• Liver-on-chip (drug metabolism and toxicity)

Microfluidic platforms and bioreactors

• Dynamic perfusion systems

• Physiologically relevant mechanical and biochemical cues

• Scalable and reproducible designs

Embedded biosensors and real-time monitoring

• Functional, metabolic and inflammatory readouts

• Quantitative and continuous data generation

Automation and robotics

• Handling of chips and tissues

• Reduction of experimental variability

• Support for higher throughput and standardisation

Artificial intelligence and virtual twin integration

• Advanced analysis of multiparametric MPS data

• Predictive modelling of drug response and toxicity

• Support to personalised and population-based simulations

Quality and regulatory readiness

• Development of devices and workflows under ISO 13485

• Design control, risk management and traceability

• Contribution to validation strategies aligned with EMA/OECD expectations