HNN3.0

Project cooperationUpdated on 16 January 2026

Mechanistic IgG biology for immune-mediated disease

Professor at Unity Health Toronto

Toronto, Canada

About

Offering expertise in mechanistic IgG biology and immune modulation, with primary application to immune-mediated non-communicable diseases. Focus areas include FcγR- and FcRn-dependent pathways, immune complex formation and clearance, heterogeneity of response to antibody-based interventions, and immune-mediated adverse effects such as cytopenias or bleeding. IVIG is used as a biological reference to interpret immunomodulatory mechanisms and inform optimisation and safety of antibody therapies. Additional expertise includes assessment of antibody-dependent enhancement (ADE) as a cross-cutting safety and risk mechanism relevant to antibody-based interventions across disease areas. Interested in contributing mechanistic and translational insight to collaborative Horizon Europe consortia where immune mechanisms, patient stratification, or therapy optimisation are central.

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