Acoustic Biomarkers to Rule In/Out Heart Failure in Patients With Acute Breathlessness

We are seeking clinical and research partners to collaborate on a prospective study evaluating Eupnoos’ non-invasive acoustic biomarker platform for rapid rule-in/rule-out assessment of heart failure in patients presenting with breathlessness in primary care and emergency settings.

Heart failure diagnosis is often delayed because breathlessness has multiple causes—cardiac, respiratory, or mixed—and existing tools such as NT-proBNP, chest X-ray, or echocardiography are episodic, resource-intensive, or unavailable at point of presentation. Eupnoos offers a 45-second breath test, captured via smartphone or a handheld microphone, that generates acoustic biomarkers correlated with congestion, restriction, obstruction, and early hemodynamic stress.

Early feasibility studies have demonstrated strong alignment with validated clinical measures such as NT-proBNP and NYHA class, suggesting potential value as a frontline triage tool to support rapid decision-making and reduce unnecessary admissions, imaging, and diagnostic uncertainty.

The study aims to:
• Evaluate diagnostic accuracy for ruling heart failure in/out
• Compare performance against NT-proBNP, echocardiography, and clinical assessment
• Assess usability in primary care and ER workflows
• Explore value for early triage and resource optimisation

We welcome interest from hospitals, primary care networks, ER departments, academic groups, and innovation hubs wishing to participate in a multi-site prospective evaluation.