CL6-2025-01-CIRCBIO-08: Seeking Research Partner for EU Proposal – Bioinformatics Expertise in Lipase Gene Mining

Project concept

Lipases are versatile biocatalysts with applications across multiple sectors including food, biofuels, pharmaceuticals, and waste valorization. However, industrial applications often require specific enzymatic properties (e.g., higher stability, altered substrate specificity, resistance to solvents or temperature), which are not always present in natural enzymes. Our project aims to identify novel lipase candidates from genomic databases, characterize them in silico, and use them as a starting point for protein engineering and optimization.

Partner profile sought

We are looking for a research group or academic institution with the following capabilities:

Expertise in bioinformatics, metagenomics, and genome mining, particularly in navigating and extracting data from large genomic repositories such as:

• NCBI GenBank

• EMBL-EBI ENA

• JGI IMG

• Other relevant specialized databases

Proven experience in:

• Identifying genes encoding specific enzymatic functions (ideally lipases or esterases)

• Applying search filters to define and extract genes with specific characteristics (e.g., sequence motifs, structure-function predictions, environmental origin)

• Performing in silico characterization of enzymatic properties (e.g., thermostability prediction, domain analysis, homology modeling)

• Familiarity with machine learning tools or bioinformatic pipelines for enzyme function prediction will be considered a plus.

  About us

AIMPLAS, the Plastics Technology Centre, is a non-profit research organization based in Valencia, Spain. With over 30 years of experience, AIMPLAS specializes in the development of innovative solutions across the entire plastics value chain, from raw materials and processing to end-of-life and recycling. Our multidisciplinary team of over 250 professionals combines expertise in materials science, biotechnology, circular economy, and sustainable processes to support companies in their R&D efforts and bring cutting-edge technologies to market.

AIMPLAS has participated in more than 200 national and European R&D projects, including Horizon Europe, H2020, LIFE, and BBI JU initiatives. We provide state-of-the-art facilities for polymer development, chemical analysis, and pilot-scale testing, as well as deep knowledge in areas such as bioplastics, functional additives, and advanced recycling technologies.

In the context of this proposal, AIMPLAS brings its extensive experience in enzyme-based processes, bio-based materials, and innovation management, ensuring technical excellence and smooth project coordination.