Technologies for anti-viral drug and cell-based influenza virus production

1.Anti-influenza virus agent- host cell interactome screens identify targetable host factors and guide antiviral drug development.

-Host factors involved in; 1)Early steps in the viral life cycle, 2) Viral genome replication/transcription,3) Virus-like particle formation, 4) Viral ribonucleoprotein incorporation into virions

-Cells with high ability to propagate influenza virus, suitable for producing the virus for manufacturing a vaccine.; 1) More easily scaled up with reduced risk of mutations, 2) Absence of egg proteins with less potential allergies, 3) Approved for human use in US and EU, 4) High vaccine virus yield

2.Irreversible Inhibitors of DNA Polymerase

•A group of compounds that irreversibly inhibit polymerases by forming covalent bonds with DNA polymerases.

•Expected applications include pharmaceuticals with novel mechanisms of action (e.g., antiviral drugs, anticancer agents). Effective even against drug‑resistant viruses.