Non-invasive measurement of tissue perfusion

Circulatory failure causes an early alteration of microcirculation and tissue perfusion. This can lead to a dysfunction or even failure of various organs, which deteriorates the prognosis of patients. Current methods for measuring tissue perfusion refer to different parameters such as central venous and mixed venous oxygen saturation and are usually invasive. Development of monitors reflecting the microcirculatory perfusion state of the patient is currently a major issue, it could allow the diagnosis and monitoring of patients to provide a better therapeutic management.

We propose a non-invasive solution to measure the tissue perfusion of a patient by monitoring the evolution of the transcutaneous-expiratory CO2 gradient, that can be thus conducted directly at the bedside. This solution could be used to help diagnosis and prognosis of patients who have conditions which frequently affect vascular reactivity and microcirculatory (shocks, diabetes, hypertension, renal failure, etc.) but also to measure the tissue condition after a transplantation. Additional study conducted through a hyperthermia test has demonstrated interesting results on the severity of the microcirculatory alteration of patients. This test could allow to manage precisely the therapeutic strategy.

Patents
FR3001626 ; WO2011024018 + worldwide nationalization