Clermont Auvergne MSCA PF Master Class: Hosting Offer on the Link between breast cancer and obesity

Obesity is a major risk factor for postmenopausal breast cancer and an unfavorable prognostic factor, influencing tumor growth, inflammation, therapeutic resistance, and recurrence. This project aims to develop a patient-specific tumoroid model exposed to an obesogenic microenvironment in order to explore the interactions between adipocytes, pro-inflammatory cytokines, and tumor cells. The analyses will integrate multi-omic and functional approaches to identify the metabolic and inflammatory signatures of obesity in breast cancer and test their impact on therapeutic sensitivity.

The project is very broad and there are various research directions that could be developed as part of a postdoctoral fellowship, including the following(other directions are possible depending on the postdoctoral fellow's interests and areas of expertise):

-Establish and characterize tumoroids derived from obese and non-obese breast cancer patients.

-Analyze the transcriptomic and metabolic differences between these tumoroids.

-Reconstitute an obesogenic microenvironment by co-culture with adipocytes and macrophages derived from human adipose tissue.

-Evaluate sensitivity to treatments (chemotherapy, hormone therapy, metabolic inhibitors).

-Identify predictive biomarkers related to obesity (cytokines, metabolites, gene expression).