Seeking candidates for MSCA Postdoctoral Fellowships to join GRENBA's myotonic dystrophy type 1 (DM1) research

We are looking for a postdoctoral fellowship to join the Grup de Recerca Neuromuscular de Badalona (GRENBA), an interdisciplinary team based at the IGTP. The group integrates clinical, experimental, and computational approaches to investigate rare neuromuscular diseases, with a particular focus on myotonic dystrophy type 1 (DM1). The fellow will contribute to the research line focused on the application of long-read sequencing technologies to study the repetitive region associated with DM1. Additionally, the candidate will develop and implement innovative transcriptomic and metabolomic methodologies aimed at uncovering novel disease mechanisms.

Candidate must comply with the MSCA Postdoctoral Fellowships 2025 (HORIZON-MSCA-2025-PF-01) eligibility criteria set by the call.

We are looking for talented and innovative scientist with a strong background in molecular genetics, genomics, bioinformatics, and/or neurobiology. We seek highly motivated researchers capable of working both independently and as part of a multidisciplinary team.

·         Ideal candidates will have demonstrated experience in two or more of the following areas:

·         Long-read sequencing technologies.

·         Analysis of repetitive DNA regions, structural variants, or somatic mosaicism.

·         Transcriptomic or epigenomic profiling.

·         Multi-omics data integration (transcriptomics, metabolomics, epigenomics).

·         Bioinformatics and data analysis in a Linux/Unix environment.

·         Rare disease research, especially in neuromuscular or neurogenetic disorders.

The research project will focus on the comprehensive characterization of the pathogenic DMPK repeat expansion associated with myotonic dystrophy type 1 (DM1), using cutting-edge long-read sequencing technologies. The specific tasks and responsibilities include:

Design and execution of experiments involving long-read sequencing to analyse repeat length, sequence interruptions, somatic mosaicism, and methylation patterns at the DMPK locus.

Bioinformatic processing and analysis of long-read data, including the development or adaptation of pipelines to study repetitive and epigenetically regulated regions.

Integration of multi-omics data, including transcriptomic and metabolomic datasets, to investigate disease mechanisms and identify potential biomarkers. 

Collaboration with clinical and experimental teams to ensure translational relevance of the findings and contributions.

Interested candidates must submit a single PDF to preaward-international@igtp.cat document containing:

• Cover letter in which the candidate should explain their motivations.

• Short CV (max 2 pages) including contact details of two referees