CorewayPredict: Personalized Flare Prevention in Chronic Inflammatory Diseases through Digital Biomarker Analysis and Flare-up Prediction

CorewayPredict is a digital health application that offers personalized and preventive disease management for individuals living with inflammatory bowel disease. The solution monitors heart rate variability through wearable devices and combines this data with daily self-reports. Based on individual biomarker patterns, machine learning algorithms can detect early warning signs of disease flares up to 14 days before symptoms begin.

This predictive approach transforms care from reactive to proactive. Patients receive tailored alerts and action-oriented recommendations to prevent or mitigate flare intensity. Clinical studies indicate that heart rate variability correlates with inflammatory activity, making it a viable marker for flare prediction.

The project is led by coreway, a health tech startup, in collaboration with the Stuttgart Media University and the University of Southern Denmark. It builds on prior feasibility studies, existing MVP prototypes, and real-world user engagement. The application is currently under regulatory development as a class IIa medical device and is expected to be certified in early 2026.

Through the PRECISEU Innovation Support Program, the project aims to:

• Pilot CorewayPredict with diverse patient groups across multiple European regions

• Harmonize regulatory pathways and prepare for CE certification

• Integrate the solution into local care pathways and clinical workflows

• Enable interoperable data use for future precision medicine applications

CorewayPredict directly contributes to the objectives of PRECISEU by advancing data-driven, patient-centered innovation in precision medicine. It strengthens cross-border collaboration, supports health system resilience, and delivers scalable digital tools to improve outcomes for millions of IBD patients across Europe.