AI peptide and protein design

AI Peptide & Protein Design at TychoGenerative & Hallucination-Based Architectures

• Harness state-of-the-art AI frameworks to drive de novo design of proteins, linear peptides, and cyclic macrocycles.

• Generate novel structural scaffolds engineered specifically for difficult target binding pockets and protein-protein interfaces.

Physics-Based & Molecular Dynamics Validation

• Integrate Molecular Dynamics (MD) simulations and free-energy profiling to validate dynamic stability and binding interactions.

• Formulate robust binding hypotheses and structural insights to de-risk downstream wet-lab synthesis and testing.

Scaffold & Multiparameter Optimization

• Execute targeted optimization strategies balancing affinity, selectivity, solubility, and conformational stability.

• Bridge digital molecular design with actionable experimental testing roadmaps to accelerate hit-to-lead execution.