Slowing the progression of chronic kidney disease based on personalised dietary strategies using digital therapeutics.

The aim of the project is to optimise dietary recommendations for patients with chronic kidney disease. This pathology, which affects 1 in 7 adults globally, places a significant burden on both patients and their families, as well as on healthcare systems, especially in advanced stages. It is one of the most expensive to treat in the world: with dialysis or transplantation. Therefore, there is a very strong urge to develop therapeutic strategies aimed at reducing kidney function decline and thus delay the need for dialysis.

To this end, all the recommendations of international scientific societies (i.e. KDIGO : Kidney Disease: Improving Global Outcomes or KDOQI: Kidney Disease Outcomes quality Initiative) are unanimous: prevention is primarily a matter of nutrition. In the context of chronic kidney disease, sodium and protein intake are the main factors that have a strong impact on the progression of the disease. Nevertheless, it is difficult for patients and healthcare professionals to identify precisely which dietary habits have the greatest impact. So, adapting the guidelines recommendations to each patient's personalized lifestyle and dietary habits is a challenging task.

That is why this project aims to optimise CKD prevention by personalising nutritional recommendations. To do this, the project relies on the development of a digital therapeutics’ solution based on connected urine analyses carried out by patients at home. It will allow healthcare professionals to analyse each patient's specific dietary habits in order to offer personalized nutritional recommendations that better fit each patient's profile. This solution will be tailored to the lifestyle and specific dietary characteristics of each population/country. The challenge of this project is to establish a method for implementing such a solution and to assess and to validate its impact on patients' compliance with dietary rules and, therefore, on the progression of their disease.