Institute of Microbiology AS CR

The Institute of Microbiology (IMIC) of the CAS represents the largest scientific body extensively exploring life cycles, molecular mechanisms and regulatory systems of various microorganisms. In the Laboratory of Antibiotic Resistance and Microbial Metabolomics we have expertise in working with ribosomes and ribosome-targeting antibiotics, ranging from the identification of ribosomal targets to structure-informed design of antibiotics that bind the ribosome. In our research we aim to define how ribosome arrest activates gene expression in an antibiotic-specific and concentration-dependent manner, and how bacteria use this antibiotic-mediated signaling to coordinate a stress response that leads to intrinsic resistance. We investigate the mechanisms of these antibiotics in clinically relevant models such as Staphylococcus, Clostridioides, and Mycobacterium species, thereby ensuring high translational applicability.