HNN3.0

Project cooperationUpdated on 2 February 2026

Insulin and IGF Signalling Mechanisms in Metabolic, Cardiovascular and Cancer Diseases

group leader at IOCB Prague

Praha, Czech Republic

About

We investigate disease-relevant molecular mechanisms of insulin and insulin-like growth factor (IGF1/2) signalling, focusing on receptor specificity, pathway selectivity and dysregulation in metabolic, cardiovascular and cancer-related conditions.

Using synthetic insulin and IGF analogues, peptide mimetics and receptor-selective tools, we dissect metabolic versus mitogenic signalling and their contribution to disease phenotypes. Our work addresses fundamental mechanisms underlying insulin resistance, altered growth signalling and hormone-driven disease progression.

We seek to contribute as a scientific partner to Horizon Europe Health projects focused on disease mechanisms, biomarkers and targeted therapeutic strategies, including topics related to cardiovascular diseases, metabolic disorders and cancer.

Topic

  • DESTINATION 3: HORIZON-HLTH-2026-01-DISEASE-03: Advancing research on the prevention, diagnosis, and management of post-infection long-term conditions
  • DESTINATION 3: HORIZON-HLTH-2026-01-DISEASE-11: Understanding of sex and/or gender-specific mechanisms of cardiovascular diseases: determinants, risk factors and pathways

Type

  • Partner seeks Consortium/Coordinator

Organisation

IOCB Prague

R&D Institution

Prague, Czech Republic

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