Project cooperationUpdated on 2 February 2026
Insulin and IGF Signalling Mechanisms in Metabolic, Cardiovascular and Cancer Diseases
group leader at IOCB Prague
Praha, Czech Republic
About
We investigate disease-relevant molecular mechanisms of insulin and insulin-like growth factor (IGF1/2) signalling, focusing on receptor specificity, pathway selectivity and dysregulation in metabolic, cardiovascular and cancer-related conditions.
Using synthetic insulin and IGF analogues, peptide mimetics and receptor-selective tools, we dissect metabolic versus mitogenic signalling and their contribution to disease phenotypes. Our work addresses fundamental mechanisms underlying insulin resistance, altered growth signalling and hormone-driven disease progression.
We seek to contribute as a scientific partner to Horizon Europe Health projects focused on disease mechanisms, biomarkers and targeted therapeutic strategies, including topics related to cardiovascular diseases, metabolic disorders and cancer.
Topic
- DESTINATION 3: HORIZON-HLTH-2026-01-DISEASE-03: Advancing research on the prevention, diagnosis, and management of post-infection long-term conditions
- DESTINATION 3: HORIZON-HLTH-2026-01-DISEASE-11: Understanding of sex and/or gender-specific mechanisms of cardiovascular diseases: determinants, risk factors and pathways
Type
- Partner seeks Consortium/Coordinator
Organisation
Similar opportunities
Project cooperation
Insulin and IGF Analogues for Targeted Modulation of Metabolic and Mitogenic Signalling
- Partner seeks Consortium/Coordinator
- DESTINATION 5: HORIZON-HLTH-2026-01-TOOL-03: Integrating New Approach Methodologies (NAMs) to advance biomedical research and regulatory testing
- DESTINATION 3: HORIZON-HLTH-2026-01-DISEASE-11: Understanding of sex and/or gender-specific mechanisms of cardiovascular diseases: determinants, risk factors and pathways
Jiri Jiracek
group leader at IOCB Prague
Praha, Czech Republic
Project cooperation
- Partner seeks Consortium/Coordinator
- DESTINATION 3: HORIZON-HLTH-2026-01-DISEASE-11: Understanding of sex and/or gender-specific mechanisms of cardiovascular diseases: determinants, risk factors and pathways
Celia Bengougam
Medical Affairs Team Leader at Withings
Paris, France
Project cooperation
Early detection of heart failure in metabolic and high-risk cardiovascular diseases
- DESTINATION 3: HORIZON-HLTH-2026-01-DISEASE-15: Scaling up innovation in cardiovascular health
- DESTINATION 5: HORIZON-HLTH-2026-01-TOOL-03: Integrating New Approach Methodologies (NAMs) to advance biomedical research and regulatory testing
- DESTINATION 1: HORIZON-HLTH-2026-01-STAYHLTH-02: Behavioural interventions as primary prevention for Non-Communicable Diseases (NCDs) among young people
- DESTINATION 3: HORIZON-HLTH-2026-01-DISEASE-11: Understanding of sex and/or gender-specific mechanisms of cardiovascular diseases: determinants, risk factors and pathways
- DESTINATION 3: HORIZON-HLTH-2026-01-DISEASE-09: Multisectoral approach to tackle chronic non-communicable diseases: implementation research maximising collaboration and coordination with sectors and in settings beyond the healthcare system (GACD)
Slavica Mitrovska
Cardiologist at Polyclinic Biotek
Skopje, North Macedonia