Medicinal Chemistry & Drug Discovery for Infectious and Neurodegenerative Diseases

The Translational Medicinal and Biological Chemistry Group at CIB Margarita Salas (CSIC), [full profile available], brings extensive expertise in drug discovery and early therapeutic development for infectious and neurodegenerative diseases, covering all stages from hit identification to lead optimization and pre‑clinical candidate generation.

The group is a validated chemistry site of the EU-OPENSCREEN ERIC.

Our team combines computational chemistry, molecular modelling, virtual screening, organic synthesis and medicinal chemistry, enabling the efficient design and optimization of small molecules with improved potency, selectivity and pharmacokinetic properties. We work across multiple therapeutic areas and targets, providing advanced capabilities for structure–guided design, SAR analysis, chemical library development and preclinical profiling.

We collaborate extensively in multidisciplinary consortia and are strongly positioned to contribute to Horizon Europe projects requiring expertise in drug discovery pipelines, small‑molecule development, mechanism‑based inhibitor design, or therapeutic innovation in infectious, neurodegenerative or other disease areas where targeted chemical interventions are needed.