iPSC-derived neuronal models in 2D and 3D

We offer a comprehensive portfolio of human iPSC-derived neuronal models in both 2D and 3D formats, including induced neurons, mixed neuronal–glial cultures, cerebral organoids, and advanced co-culture systems (e.g. neuron–glia and tumor–brain organoid models).

Our models are primarily applied to the study of neurodegenerative and neuropsychiatric disorders, with a strong focus on Alzheimer’s disease, glioblastoma, and schizophrenia, as well as gene- and pathway-specific mechanisms underlying neuronal dysfunction, neuroinflammation, and treatment resistance.

Available assays and readouts include:

• standard molecular biology assays (qPCR, WB, ELISA, FACS)

• immunocytochemistry and histology,

• fluorescent microscopy, high-content and live-cell imaging,

• electron microscopy (SEM, TEM)

• single-cell and bulk RNA sequencing,

• proteomics and pathway analysis,

• electrophysiology (MEA),

• calcium imaging,

• functional assays of trafficking, synaptic activity, and cell viability,

• drug and inhibitor testing in 2D cultures, organoids, and tumoroids.

These platforms enable mechanistic studies, target validation, and preclinical drug testing in human-relevant neuronal systems.