Novel "Innate" Approaches for Vaccines in Low- and Middle-Income Countries

This project will try to offer a different point-of-view from the pathogen-specific vaccination to a broad-spectrum innate immune preparedness. Novel "vaccine" formulations designed to potently and safely modulate the innate immune system can establish a "quick protectio" of against new viruses. This "trained" or "broadly reactive" immunity could act as a universal first line of defense, controlling early viral replication and reducing severe disease from novel pathogens, independent of a specific vaccine.

The core strategy is to enhance innate immune pathways that are common to many viral families. This approach seeks to provide immediate, cross-protective benefits, buying crucial time for the development and global distribution of specific vaccines.