Sex- and Gender-Informed Pathways and Risk Models to Reduce Cardiovascular Disease Burden

The aim of this project is to deliver a step change in cardiovascular disease research and care by systematically uncovering, integrating, and translating sex- and gender-specific health determinants, risk factors, and biological pathways into actionable prevention, diagnostic, and treatment strategies. By combining multidisciplinary mechanistic research with large-scale analysis of existing European cohorts, registries, and biobanks, and by leveraging advanced digital technologies, including artificial intelligence, the project will generate and validate robust sex- and gender-tailored risk models that capture life-course dynamics, hormonal influences, and intersecting biological and sociocultural factors. Through the meaningful integration of biomedical sciences with social sciences and humanities, the project will bridge the long-standing gap between sex-specific discovery and clinical implementation, enabling earlier detection, more accurate diagnosis, and more effective, personalised interventions for women and men. Ultimately, the project will provide healthcare systems with innovative, evidence-based strategies that improve equity, enhance clinical decision-making, and contribute to a sustained reduction in the burden of cardiovascular diseases across Europe