Juan A. Rosado

Juan Antonio Rosado is a Full Professor in the Department of Physiology at the University of Extremadura. After his PhD in 1997, he carried out a postdoctoral stay at the Department of Physiology at the University of Cambridge (UK), where he began developing an interest in the mechanisms underlying the activation and maintenance of store-operated calcium entry (SOCE). His research has focused on calcium signaling, particularly calcium entry, in both excitable and non-excitable cells, including the molecular components and regulatory proteins involved, as well as their role in cellular physiology.

Throughout his scientific career, he has identified novel proteins essential for the activation of store-operated calcium entry and has described regulatory mechanisms that have been highly influential in subsequent studies of calcium entry activation. In the last decade, his work has also explored the remodeling of store-operated calcium entry in the context of pathologies such as diabetes mellitus, cardiovascular disorders and cancer—with particular focus on channel and expression and function remodeling in cancer cells and cancer stem cells during the development of key features of breast cancer cells such as proliferation, invasion, chemo-resistance and survival.

His research has led to the publication of more than 250 scientific articles and 26 book chapters, and he has led 6 national research projects, among others. He served on the editorial board of journals such as The Journal of Biological Chemistry (2010–2015), and he is currently a member of the editorial board of journals such as Biochimica et Biophysica Acta (BBA) and Cell Calcium.